abstract：:Al adjuvants are used in vaccines to increase the immune response. NTPDase and AChE play a pivotal role and act in the regulation of the immune system. The effect of Al exposure in vitro and in vivo on NTPDase and AChE activities in the lymphocytes of rats was determined. In vitro, ATP hydrolysis was decreased by 20.4...

journal_title：Cellular immunology

authors： Kaizer RR,Gutierres JM,Schmatz R,Spanevello RM,Morsch VM,Schetinger MR,Rocha JB

更新日期：2010-01-01 00:00:00

abstract：:The objective of this investigation was to explore possible molecular changes for role of a high-fat diet (HFD)-induced oxidative stress in splenic lymphocytes, and whether a dietary lipoic acid (LA) supplement could attenuate these changes. Male C57BL/6 mice were fed one of three diets 10 weeks and outcome measures c...

journal_title：Cellular immunology

authors： Cui J,Xiao Y,Shi Y,Le G,Miao X

更新日期：2010-01-01 00:00:00

abstract：:Receptors for the Fc domain of IgG mediate target recognition, signal transduction, and effector functions including antibody-dependent cytolysis, phagocytosis, and phagolysosome formation. To better understand FcR-mediated functions and to identify potential therapeutic strategies, we employed cell-penetrating ("Troj...

journal_title：Cellular immunology

authors： Clark AJ,Petty HR

更新日期：2010-01-01 00:00:00

abstract：:An Affymetrix mouse genome array and differential in-gel electrophoresis (DIGE) techniques were used to investigate the pharmacological mechanisms of a mixture of herbs, designated CTCM, a compound of traditional Chinese medicine, for the treatment of increased permeability in mouse intestinal microvascular endothelia...

journal_title：Cellular immunology

authors： Yi P,Guo Y,Wang X,Mu X,Wei X

更新日期：2010-01-01 00:00:00

abstract：:Lenalidomide, a daughter molecule of Thalidomide, and IMIDs are immunomodulatory drugs that have been described as having immunomodulatory properties and anti-tumor activity. The effect of Lenalidomide towards Peripheral Blood Mononuclear Cells (PBMC) has been studied and direct effects towards T cells have been descr...

journal_title：Cellular immunology

authors： Dauguet N,Fournié JJ,Poupot R,Poupot M

更新日期：2010-01-01 00:00:00

abstract：:CXCL10 production is a critical step in limiting mycobacterial infection. Although induction of this chemokine by mycobacteria in epithelial cells has been reported, it is still unclear how CXCL10 is regulated in Mycobacterium bovis BCG-infected epithelial cells. In this study, we demonstrate that phosphatidylinoditol...

journal_title：Cellular immunology

authors： Méndez-Samperio P,Pérez A,Rivera L

更新日期：2009-01-01 00:00:00

abstract：:Senescence is characterized by several alterations in the immune system. Such modifications can be found in lymphoid organs as well as in the cellular components of the immune system. Several reports have suggested that immune dysfunction can affect both T and B cells, but T cells have been shown to be more susceptibl...

journal_title：Cellular immunology

authors： Speziali E,Santiago AF,Fernandes RM,Vaz NM,Menezes JS,Faria AM

更新日期：2009-01-01 00:00:00

abstract：:Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation in murine allergic a...

journal_title：Cellular immunology

authors： Shilling RA,Clay BS,Tesciuba AG,Berry EL,Lu T,Moore TV,Bandukwala HS,Tong J,Weinstock JV,Flavell RA,Horan T,Yoshinaga SK,Welcher AA,Cannon JL,Sperling AI

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-23, composed of p19 and p40 subunits, has diverse functions in regulating immune systems, enhancing cell-mediated immunity. In the present study, we investigated whether forced expression of the p19-linked p40 gene in murine mammary cancer cells (MA891) produced antitumor effects in vivo. Tu...

journal_title：Cellular immunology

authors： Liu L,Shan B,Feng Y

更新日期：2009-01-01 00:00:00

abstract：:Peripheral CD4+CD8+ T cells have been identified as a T cell subset existing in animals and humans. However, the characterization of CD4+CD8+ T cells, their relationship with T memory (T(M)), T effector (T(E)), Th1/Th2, Treg and Th-17, remain unclear. This study was to characterize the CD4+CD8+ T cells. The results fr...

journal_title：Cellular immunology

authors： Xie D,Hai B,Xie X,Liu L,Ayello J,Ma X,Zhang J

更新日期：2009-01-01 00:00:00

abstract：:Activin A is a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily and acts as an anti-inflammatory cytokine produced by microglia and macrophages. In this study, we investigated the regulatory effect and possible mechanism of activin A on activation of lipopolysaccharide (LPS)-induced...

journal_title：Cellular immunology

authors： Zhou J,Tai G,Liu H,Ge J,Feng Y,Chen F,Yu F,Liu Z

更新日期：2009-01-01 00:00:00

abstract：:Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a beta-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth. Histopathological analysis showed that the tumor masses of control mice (Ehr) presented giant tumor cells and many mitotic figures whereas the tumor ti...

journal_title：Cellular immunology

authors： Pinto AV,Martins PR,Romagnoli GG,Campanelli AP,Terezan AP,Filho ER,Ferreira da Eira A,Kaneno R

更新日期：2009-01-01 00:00:00

abstract：:Peroxynitrite (ONOO(-)) has been vastly implicated in mutagenesis and cancer development. Present study probes the antigenicity of peroxynitrite damaged DNA (ONOO(-)-DNA) in cancer patients. Purified human placental DNA was damaged by the synergistic action of sodium nitroprusside (SNP) and Pyrogallol for 3h at 37 deg...

journal_title：Cellular immunology

authors： Habib S,Moinuddin,Ali A,Ali R

更新日期：2009-01-01 00:00:00

abstract：:Activation of lck-fyn kinases during T cell receptor signaling leads to Vav phosphorylation, activation of downstream targets including Rac1, and a transient decline in ezrin and moesin phosphorylation. We have shown that age increases Rac1 activity and lowers ezrin and moesin phosphorylation in resting mouse CD4 cell...

journal_title：Cellular immunology

authors： Garcia GG,Miller RA

更新日期：2009-01-01 00:00:00

abstract：:The Interferon-inducible gene IFI16, a member of the HIN200 family, is activated by oxidative stress and cell density, in addition to Interferons, and it is implicated in the regulation of endothelial cell proliferation and vessel formation in vitro. We have previously shown that IFI16 is required for proinflammatory ...

journal_title：Cellular immunology

authors： Sponza S,De Andrea M,Mondini M,Gugliesi F,Gariglio M,Landolfo S

更新日期：2009-01-01 00:00:00

abstract：:Mutations in the X-linked inhibitor of apoptosis (XIAP) have recently been identified in patients with the rare genetic disease, X-linked lymphoproliferative syndrome (XLP), which was previously thought to be solely attributable to mutations in a distinct gene, SAP. To further understand the roles of these two factors...

journal_title：Cellular immunology

authors： Rumble JM,Oetjen KA,Stein PL,Schwartzberg PL,Moore BB,Duckett CS

更新日期：2009-01-01 00:00:00

abstract：:The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we ...

journal_title：Cellular immunology

authors： Andrade CF,Gameiro J,Nagib PR,Carvalho BO,Talaisys RL,Costa FT,Verinaud L

更新日期：2008-05-01 00:00:00

abstract：:Vibrio vulnificus, a pathogenic bacterium causing primary septicemia, exhibited cytotoxicity towards Jurkat cells of T-lymphocytes through intracellular reactive oxygen species (ROS) production. Pretreatment of Jurkat T-cells with diphenyleneiodonium chloride (DPI) abolished V. vulnificus-induced ROS generation and ba...

journal_title：Cellular immunology

authors： Kim WH,Goo SY,Shin MH,Chun SJ,Lee H,Lee KH,Park SJ

更新日期：2008-05-01 00:00:00

abstract：:Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to accelerate the recovery of the immune response after chemotherapy and bone marrow transplantation and to enhance the restoration of immunity in individuals infected with HIV and in normal individuals with compromised immu...

journal_title：Cellular immunology

authors： Redelman D,Welniak LA,Taub D,Murphy WJ

更新日期：2008-03-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are promising candidates for developing cell therapies for intractable diseases. To assess the feasibility of transplantation with human umbilical cord blood (hUCB)-derived MSCs, we analyzed the ability of these cells to function as alloantigen-presenting cells (APC) in vitro. hUCB-MSC...

journal_title：Cellular immunology

authors： Oh W,Kim DS,Yang YS,Lee JK

更新日期：2008-02-01 00:00:00

abstract：:Modification of cytokine production by gender hormones has been postulated to affect disease susceptibility and outcome. Here we investigate the effect of gender and the menstrual cycle on production of cytokines. Mononuclear cells were isolated every week for 10 consecutive weeks from healthy pre-menopausal women and...

journal_title：Cellular immunology

authors： Temple SE,Pham K,Glendenning P,Phillips M,Waterer GW

更新日期：2008-02-01 00:00:00

abstract：:Chemokine receptors CCR5 and CXCR4 are of major importance in the pathogenesis of HIV-1 infection because they are co-receptors for human immunodeficiency virus (HIV) entry. We examined the frequency of CD3-CD56+CCR5+ and CD3-CD56+CXCR4+ in HIV-infected long-term slow progressors (SPs), HIV typical progressors (TPs) w...

journal_title：Cellular immunology

authors： Jiang Y,Zhang Z,Diao Y,Jin X,Shi W,Geng W,Dai D,Zhang M,Han X,Liu J,Wang Y,Shang H

更新日期：2008-01-01 00:00:00

abstract：:PICOT (PKC-interacting cousin of thioredoxin) consists of one thioredoxin homology domain in the N-terminal and two tandem PICOT homology domains in the C-terminal. PICOT specifically interacts with protein kinase C theta (PKC-theta) via its thioredoxin homology domain and acts as an important modulator of T cell rece...

journal_title：Cellular immunology

authors： Kato N,Motohashi S,Okada T,Ozawa T,Mashima K

更新日期：2008-01-01 00:00:00

abstract：:Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strate...

journal_title：Cellular immunology

authors： Alves AC,Ramaldes GA,Oliveira MC,Cardoso VN,Mota-Santos TA,Faria AM,Gontijo CM

更新日期：2008-01-01 00:00:00

abstract：:Facilitating cells (FC) are bone marrow-derived cells that facilitate allogeneic hematopoietic stem cell (SC) engraftment and induce transplantation tolerance without causing graft vs. host disease. Although there is evidence for FC directing the development of FoxP3+CD4+CD25+ regulatory T cells, the specific FC subse...

journal_title：Cellular immunology

authors： Taylor KN,Laszkowska M,Cohick E,Colson YL

更新日期：2008-01-01 00:00:00

abstract：:In this study, we demonstrate that HIV-1 Tat protein is able to induce IL-10 and TNF-alpha in human macrophages. We show that N-terminal Tat 1-45 fragment initiates the PKC pathway by acting at the membrane. Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha pr...

journal_title：Cellular immunology

authors： Leghmari K,Contreras X,Moureau C,Bahraoui E

更新日期：2008-01-01 00:00:00

abstract：:Activated natural killer T (NKT) cells produce a broad range of cytokines, including IL-4 and IFN-gamma, that determine immunomodulatory functions in various animal models. In this report, we show that a well-known proinflammatory cytokine, IL-17 is also produced by a distinct population of NKT cells upon TCR stimulat...

journal_title：Cellular immunology

authors： Lee KA,Kang MH,Lee YS,Kim YJ,Kim DH,Ko HJ,Kang CY

更新日期：2008-01-01 00:00:00

abstract：:We compared TLR responsiveness in PBMC from HIV-1-infected and uninfected individuals using the TLR agonists: TLR7 (3M-001), TLR8 (3M-002), and TLR7/8 (3M-011). Activation and maturation of plasmacytoid dendritic cells (pDC) were measured by evaluating CD86, CD40, and CD83 expression and myeloid dendritic cell (mDC) a...

journal_title：Cellular immunology

authors： Martinson JA,Roman-Gonzalez A,Tenorio AR,Montoya CJ,Gichinga CN,Rugeles MT,Tomai M,Krieg AM,Ghanekar S,Baum LL,Landay AL

更新日期：2007-11-01 00:00:00

abstract：:Pentraxin 3 (PTX3) is a prototype protein of long pentraxin. PTX3 is produced by various cells, such as monocytes/macrophages (Mphis) in response to lipopolysaccharide (LPS) and proinflammatory signals. We performed immunoblotting, immunohistochemical staining, reverse transcriptase-polymerase chain reaction (RT-PCR),...

journal_title：Cellular immunology

authors： Imamura M,Kawasaki T,Savchenko AS,Ohashi R,Jiang S,Miyamoto K,Ito Y,Iwanari H,Sagara M,Tanaka T,Hamakubo T,Kodama T,Uchiyama M,Naito M

更新日期：2007-08-01 00:00:00

abstract：:The long-term exposure of mice to superantigen SEA using a mini-osmotic pump (SEA pump) induced a long-lasting expansion of Vbeta3+ CD4+ T cells with T helper (Th) 2 cell-type properties. Removal of the SEA pump 10 days after pump implantation did not significantly alter the level of Vbeta3+ CD4+ T cell expansion/main...

journal_title：Cellular immunology

authors： Koyanagi M,Fukada K,Uchiyama T,Yagi J,Arimura Y

更新日期：2007-08-01 00:00:00

abstract：:Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in response to foreign, endogenous and synthetic ligands including viral dsRNA, bacterial RNA, mitochondrial RNA, endogenous necrotic cell mRNA and the synthetic dsRNA an...

journal_title：Cellular immunology

authors： Duffy KE,Lamb RJ,San Mateo LR,Jordan JL,Canziani G,Brigham-Burke M,Korteweg J,Cunningham M,Beck HS,Carton J,Giles-Komar J,Duchala C,Sarisky RT,Mbow ML

更新日期：2007-08-01 00:00:00

abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

journal_title：Cellular immunology

authors： Shen C,Zhang J,Xia L,Meng F,Xie W

更新日期：2007-05-01 00:00:00

abstract：:Overexpression of TNF-alpha in the body is critically involved in many diseases. A strategy to construct TNF-alpha autovaccine by introducing a T cell helper epitope to the protein has been developed and may be an alternative because it is cheaper and highly efficient. However, the induction of high level anti-TNF-alp...

journal_title：Cellular immunology

authors： Wan Y,Xue X,Li M,Zhang X,Qin X,Zhang C,You Y,Wang W,Jiang C,Wu S,Liu Y,Zhu W,Ran Y,Zhang Z,Han W,Zhang Y

更新日期：2007-04-01 00:00:00

abstract：:The relay hypothesis [R. Nayak, S. Mitra-Kaushik, M.S. Shaila, Perpetuation of immunological memory: a relay hypothesis, Immunology 102 (2001) 387-395] was earlier proposed to explain perpetuation of immunological memory without requiring long lived memory cells or persisting antigen. This hypothesis envisaged cycles ...

journal_title：Cellular immunology

authors： Vani J,Nayak R,Shaila MS

更新日期：2007-03-01 00:00:00

abstract：:Patients treated with monoclonal antibodies and cytokines for cancer receive often co-medication, which may influence treatment efficacy. Therefore, we investigated with a flowcytometric cytotoxicity assay the effect of several immunomodulatory drugs on antibody dependent cellular cytotoxicity (ADCC), interleukin-2 (I...

journal_title：Cellular immunology

authors： Flieger D,Varvenne M,Kleinschmidt R,Schmidt-Wolf IG

更新日期：2007-03-01 00:00:00

abstract：:The loss of thymic function with age may be due to diminished numbers of T-cell progenitors and the loss of critical mediators within the thymic microenvironment. To assess the molecular changes associated with this loss, we examined transcriptomes of progressively aging mouse thymi, of different sexes and on caloric-...

journal_title：Cellular immunology

authors： Lustig A,Weeraratna AT,Wood WW 3rd,Teichberg D,Bertak D,Carter A,Poosala S,Firman J,Becker KG,Zonderman AB,Longo DL,Taub DD

更新日期：2007-01-01 00:00:00

abstract：:Basic Immunology has had only two significant public priority disputes. The first began in the late 1650s and concerned the recognition of the peripheral network of vessels which collects lymph throughout the body. The publication of this major anatomical discovery prompted a priority feud discussed in a previous pape...

journal_title：Cellular immunology

authors： Ambrose CT

更新日期：2007-01-01 00:00:00

abstract：:The effect of low-dose irradiation on the immune system was investigated in mice. When a 0.2 Gy dose of X-ray irradiation was administered every other day for a total of four times, the number of lymphocytes yielded by the liver, spleen and thymus decreased at the initial stage (around day 10). At this stage, NK cells...

journal_title：Cellular immunology

authors： Ren H,Shen J,Tomiyama-Miyaji C,Watanabe M,Kainuma E,Inoue M,Kuwano Y,Abo T

更新日期：2006-11-01 00:00:00

abstract：:Although CD4(+)CD25(+) regulatory T cells are pivotal in the suppression of autoimmunity, little is known about the effect of antigen-specific regulatory T cells on the formation of atheromatous plaques. Here, we describe the induction of heat-shock protein 60 (HSP60)-specific CD4(+)CD25(high) T cells by rapamycin (RP...

journal_title：Cellular immunology

authors： Yang K,Li D,Luo M,Hu Y

更新日期：2006-10-01 00:00:00

abstract：:Observational studies in multiple sclerosis (MS) demonstrated altered expression of chemokine receptors (CkRs) on comparable populations of mononuclear cells (e.g. CD4(+)/CD45RO(+) T-cells) in brain sections compared with blood. These findings raised questions about the regulation of CkRs on trafficking cells. Regulat...

journal_title：Cellular immunology

authors： Ubogu EE,Callahan MK,Tucky BH,Ransohoff RM

更新日期：2006-09-01 00:00:00